stubborn

adjective

tenaciously unwilling or marked by tenacious unwillingness to yield
執拗に嫌がる、あるいは放棄するために執拗に嫌がることにより特徴付けられる
not responding to treatment
処置に応じないさま
- a stubborn infection
  頑固な感染
- a refractory case of acne
  にきびの難治例
- stubborn rust stains
  しつこいさび汚れ

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